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The immunometabolic axis of sepsis-related myocardial injury: macrophage reprogramming as a central mechanism and therapeutic target

Sepsis-related myocardial injury (SRMI) is a major cause of death in critically ill patients, with pathogenesis extending beyond inflammation to encompass dysregulated immunometabolic crosstalk. This review elucidates macrophage metabolic reprogramming as a central mechanism driving SRMI, detailing...

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Principais autores: Yuyang Qiu, Hongying Bi, Wei Xie, Jiao Zhao, Tian Zhang, Jianyu Fu, Xu Liu, Guiyun Li
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-03-01
coleção:Frontiers in Immunology
Assuntos:
exosomes
immunometabolism
macrophage polarization
metabolic reprogramming
mitochondria
sepsis-related myocardial injury
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1779575/full
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