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Distinct amyloid fibril structures formed by ALS-causing SOD1 mutants G93A and D101N

Abstract Two hundred eight genetic mutations in SOD1 have been linked to amyotrophic lateral sclerosis (ALS). Of these, the G93A and D101N variants maintain much of their physiological function, closely resembling that of wild-type SOD1, and the SOD1-G93A transgenic mouse is the most extensively use...

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Principais autores: Mu-Ya Zhang, Yeyang Ma, Li-Qiang Wang, Wencheng Xia, Xiang-Ning Li, Kun Zhao, Jie Chen, Dan Li, Liangyu Zou, Zhengzhi Wang, Cong Liu, Yi Liang
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2025-08-01
Serier:EMBO Reports
Fag:
Amyotrophic Lateral Sclerosis (ALS)
SOD1 Mutants
Amyloid Fibrils
Cryo-EM Structure
Toxicity
Online adgang:https://doi.org/10.1038/s44319-025-00557-8
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