Regulatory T cells define affinity thresholds for CD8+ T cell tumor infiltration
Abstract TCR repertoires against tumors lack high-affinity TCRs and are further suppressed by Tregs. We hypothesized that Treg depletion enhances the antitumor efficacy of low-affinity T cells. Using the weak agonistic peptide A4Y derived from LCMV glycoprotein peptide p33 as a model antigen and VLP...
Na minha lista:
| Principais autores: | , , , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2025-06-01
|
| coleção: | npj Vaccines |
| Acesso em linha: | https://doi.org/10.1038/s41541-025-01177-y |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|