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TCF12-regulated GRB7 facilitates the HER2+ breast cancer progression by activating Notch1 signaling pathway

Abstract Background Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC), which accounts for approximately one-fifth of all BCs, are highly invasive with a high rate of recurrence and a poor prognosis. Several studies have shown that growth factor receptor-bound protein 7 (GR...

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Главные авторы: Gang Wang, Yuanli Wu, Yue Su, Na Qu, Bo Chen, Duanfang Zhou, Lie Yuan, Manjialan Yin, Mingpu Liu, Weiying Zhou
Формат: Artigo
Язык:Inglês
Опубликовано: BMC 2024-08-01
Серии:Journal of Translational Medicine
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Online-ссылка:https://doi.org/10.1186/s12967-024-05536-6
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