Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

Therapeutic targeting FOXO3A (a forkhead transcription factor) represents a promising strategy to suppress acute myeloid leukemia (AML). However, the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOXO3A depletion on AML cells....

Descrizione completa

Dettagli Bibliografici

Autori principali:	Zhe Chen, Qian Guo, Shichen Huang, Lei Li, Feng Wu, Zhilong Liu, Zhigang Li, Tao Chen, Guanbin Song, Shuangnian Xu, Jieping Chen, Yu Hou
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	KeAi Communications Co., Ltd. 2024-01-01
Serie:	Genes and Diseases
Soggetti:	AML Combinatorial inhibition FOXO3A GNG7 mTOR
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2352304223000107
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!