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Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Abstract Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular disease being the main cause of death. Cells from HGPS patients accumulate progerin, a permanently farnesylated, toxic form of Lamin A, disr...

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Principais autores: Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2018-04-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-018-03770-3
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