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Copy Number Variation of Human Satellite III (1q12) With Aging

Introduction: Human satellite DNA is organized in long arrays in peri/centromeric heterochromatin. There is little information about satellite copy number variants (CNVs) in aging and replicative cell senescence (RS).Materials and Methods: Biotinylated pUC1.77 probe was used for the satellite III (f...

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Principais autores: Elizaveta S. Ershova, Elena M. Malinovskaya, Marina S. Konkova, Roman V. Veiko, Pavel E. Umriukhin, Andrey V. Martynov, Sergey I. Kutsev, Natalia N. Veiko, Svetlana V. Kostyuk
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019-08-01
Serija:Frontiers in Genetics
Teme:
copy number variance
satellite DNA
aging
replicative senescence
genotoxic stress response
Online dostop:https://www.frontiersin.org/article/10.3389/fgene.2019.00704/full
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