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Formulation of Chewable Tablets Containing Carbamazepine-β-cyclodextrin Inclusion Complex and F-Melt Disintegration Excipient. The Mathematical Modeling of the Release Kinetics of Carbamazepine

Due to its low solubility, carbamazepine (CBZ) exhibits slow and incomplete release in the gastrointestinal tract and, hence, variable pharmacokinetics and pharmacodynamic effect. Lots of methods have been devised to improve its solubility, the large number of proposed solutions being a sign that th...

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Principais autores: Adina Magdalena Musuc, Valentina Anuta, Irina Atkinson, Iulian Sarbu, Vlad Tudor Popa, Cornel Munteanu, Constantin Mircioiu, Emma Adriana Ozon, George Mihai Nitulescu, Mirela Adriana Mitu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-06-01
coleção:Pharmaceutics
Assuntos:
carbamazepine
β-cyclodextrin
release kinetics
inclusion complex
F-Melt excipient
chewable tablets
Acesso em linha:https://www.mdpi.com/1999-4923/13/6/915
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