Double Mutation at the Putative Protein Kinase C Phosphorylation Sites Thr151 Plus Thr323 in the Mouse LeukotrieneD4 Receptor Eliminates Homologous Desensitization

Background/Aims: Signalling via CysLT1 is involved in activation of volume sensitive K+ channels and homologous desensitization of the LTD4 receptor impairs regulatory volume decrease (RVD). The aim is to illustrate the effect of mutation of putative PKC consensus phosphorylation sites in the CysLT1...

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Autors principals:	Sune T. Jørgensen, Heidi N. Eriksen, Janni Dausell, Thomas Jespersen, Ian H. Lambert, Else K. Hoffmann
Format:	Artigo
Idioma:	Inglês
Publicat:	Cell Physiol Biochem Press GmbH & Co KG 2013-03-01
Col·lecció:	Cellular Physiology and Biochemistry
Matèries:	CysLT1 LTD4 Desensitization Xenopus laevis
Accés en línia:	http://www.karger.com/Article/FullText/343374
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