Benzo[a]pyrene exacerbates allergen-induced airway inflammation through NLRP3-dependent dendritic cell activation and pathogenic T helper cell polarization

BackgroundEnvironmental pollutants are known to aggravate allergic diseases, but the molecular mechanisms by which polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) potentiate allergic airway inflammation remain poorly understood.ObjectiveWe investigated how BaP co-exposure modifies hous...

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Autors principals:	Huamei Zou, Jiaqi Duan, Yongmin Xie, Ruien Chen, Yanyu Ye, Aizhi Zhang, Pingchang Yang, Gui Yang, Xiaoyu Liu
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-11-01
Col·lecció:	Frontiers in Immunology
Matèries:	benzo[a]pyrene house dust mite asthma airway inflammation dendritic cells NLRP3 inflammasome
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1699886/full
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