Impaired Cardiac AMPK (5′‐Adenosine Monophosphate‐Activated Protein Kinase) and Ca2+‐Handling, and Action Potential Duration Heterogeneity in Ibrutinib‐Induced Ventricular Arrhythmia Vulnerability

Background We recently demonstrated that acute administration of ibrutinib, a Bruton's tyrosine kinase inhibitor used in chemotherapy for blood malignancies, increases ventricular arrhythmia (VA) vulnerability. A pathway of ibrutinib‐induced vulnerability to VA that can be modulated for cardioprotec...

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Principais autores:	Yanan Zhao, Beibei Du, Praloy Chakraborty, Nathan Denham, Stéphane Massé, Patrick F.H. Lai, Mohammed Ali Azam, Filio Billia, Paaladinesh Thavendiranathan, Husam Abdel‐Qadir, Gary D. Lopaschuk, Kumaraswamy Nanthakumar
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2024-06-01
Series:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:	action potential AMPK calcium handling ibrutinib ventricular arrhythmias
Acceso en liña:	https://www.ahajournals.org/doi/10.1161/JAHA.123.032357
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