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From maternal microbes to offspring development: gut microbiota-derived thiamine regulates the gut microbiota and drives the placental Notch pathway to coordinate angiogenesis and nutrient transport

Abstract Background The maternal gut microbiota can modulate host physiological homeostasis through metabolites. Maternal reproductive potential hinges on placental angiogenesis and nutrient transport efficiency, directly determining fetal developmental outcomes. However, the specific molecular mech...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Guodong Sun, Ze Wang, Xing Guo, Haoyang Sun, Teng Teng, Baoming Shi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-12-01
Schriftenreihe:Microbiome
Schlagworte:
Microbiota
Metabolome
Thiamine
Placenta
Angiogenesis
Online-Zugang:https://doi.org/10.1186/s40168-025-02317-1
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