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Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology

Intrahippocampal injection of the murine modified scrapie (ME7) induces a model of prion disease in vivo. Animals inoculated with ME7 brain homogenate were compared to controls at 8, 12 and 21 weeks. The data show that the accumulation of misfolded prion (PrPSc) coincided with selective reduction in...

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Bibliografische gegevens
Hoofdauteurs: Bryony C. Gray, Zuzana Siskova, V. Hugh Perry, Vincent O'Connor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2009-07-01
Reeks:Neurobiology of Disease
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Online toegang:http://www.sciencedirect.com/science/article/pii/S0969996109000783
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