EGFR-Mutated Lung Adenocarcinoma Successfully Treated With Osimertinib After Spontaneous Transformation to SCLC and Adenocarcinoma With Neuroendocrine Differentiation: Case Report

Lineage transformation from lung adenocarcinoma (LUAD) to SCLC is associated with resistance to EGFR tyrosine kinase inhibitors. In addition to loss of p53 and RB, transformed SCLCs are usually not dependent on EGFR signaling, which renders the tumors unresponsive to EGFR tyrosine kinase inhibitors....

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Manylion Llyfryddiaeth

Prif Awduron:	Sho Takuma, MD, Yusuke Inoue, MD, PhD, Masato Karayama, MD, PhD, Kazuo Tsuchiya, MD, Hiroe Tsukui, MD, Hironao Hozumi, MD, PhD, Yuzo Suzuki, MD, PhD, Kazuki Furuhashi, MD, PhD, Noriyuki Enomoto, MD, PhD, Tomoyuki Fujisawa, MD, PhD, Yutaro Nakamura, MD, PhD, Naoki Inui, MD, PhD, Takafumi Suda, MD, PhD
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2022-01-01
Cyfres:	JTO Clinical and Research Reports
Pynciau:	Spontaneous transformation Neuroendocrine EGFR Small cell lung cancer Case report
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2666364321001235
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!