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Human Brain Microvascular Endothelial Cells Exposure to SARS-CoV-2 Leads to Inflammatory Activation through NF-κB Non-Canonical Pathway and Mitochondrial Remodeling

Neurological effects of COVID-19 and long-COVID-19, as well as neuroinvasion by SARS-CoV-2, still pose several questions and are of both clinical and scientific relevance. We described the cellular and molecular effects of the human brain microvascular endothelial cells (HBMECs<i>)</i> in vitro expo...

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Principais autores: Carolline Soares Motta, Silvia Torices, Barbara Gomes da Rosa, Anne Caroline Marcos, Liandra Alvarez-Rosa, Michele Siqueira, Thaidy Moreno-Rodriguez, Aline da Rocha Matos, Braulia Costa Caetano, Jessica Santa Cruz de Carvalho Martins, Luis Gladulich, Erick Loiola, Olivia R. M. Bagshaw, Jeffrey A. Stuart, Marilda M. Siqueira, Joice Stipursky, Michal Toborek, Daniel Adesse
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-03-01
Serier:Viruses
Fag:
COVID-19
blood–brain barrier
mitochondrial dynamics
NF-κB signaling pathway
endothelial activation
Online adgang:https://www.mdpi.com/1999-4915/15/3/745
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