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De novo identification of universal cell mechanics gene signatures

Cell mechanical properties determine many physiological functions, such as cell fate specification, migration, or circulation through vasculature. Identifying factors that govern the mechanical properties is therefore a subject of great interest. Here, we present a mechanomics approach for establish...

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Furkejuvvon:
Váldodahkkit: Marta Urbanska, Yan Ge, Maria Winzi, Shada Abuhattum, Syed Shafat Ali, Maik Herbig, Martin Kräter, Nicole Toepfner, Joanne Durgan, Oliver Florey, Martina Dori, Federico Calegari, Fidel-Nicolás Lolo, Miguel Ángel del Pozo, Anna Taubenberger, Carlo Vittorio Cannistraci, Jochen Guck
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: eLife Sciences Publications Ltd 2025-02-01
Ráidu:eLife
Fáttát:
mechanical phenotype
deformability cytometry
transcriptomics
mechanomics
unsupervised machine learning
discriminative network analysis
Liŋkkat:https://elifesciences.org/articles/87930
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