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Targeting of pseudorabies virus structural proteins to axons requires association of the viral Us9 protein with lipid rafts.

The pseudorabies virus (PRV) Us9 protein plays a central role in targeting viral capsids and glycoproteins to axons of dissociated sympathetic neurons. As a result, Us9 null mutants are defective in anterograde transmission of infection in vivo. However, it is unclear how Us9 promotes axonal sorting...

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Autori principali: Mathew G Lyman, Dusica Curanovic, Lynn W Enquist
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2008-05-01
Serie:PLoS Pathogens
Accesso online:http://europepmc.org/articles/PMC2361720?pdf=render
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