Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities
Several genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) have been shown to increase the risk of developing Alzheimer’s disease (AD) supporting a role of microglia and immune cells in the pathobiology of AD. We have employed an ectopic model of TREM2 and DAP12 express...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Media S.A.
2019-10-01
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| Col·lecció: | Frontiers in Cellular Neuroscience |
| Matèries: | |
| Accés en línia: | https://www.frontiersin.org/article/10.3389/fncel.2019.00457/full |
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