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BICC1 interacts with PKD1 and PKD2 to drive cystogenesis in ADPKD

Autosomal-dominant polycystic kidney disease (ADPKD) is primarily of adult-onset and caused by pathogenic variants in PKD1 or PKD2. Yet, disease expression is highly variable and includes very early-onset PKD presentations in utero or infancy. In animal models, the RNA-binding molecule Bicc1 has bee...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Uyen Tran, Andrew J Streets, Devon Smith, Eva Decker, Annemarie Kirschfink, Lahoucine Izem, Jessie M Hassey, Briana Rutland, Manoj K Valluru, Jan Hinrich Bräsen, Elisabeth Ott, Daniel Epting, Tobias Eisenberger, Albert CM Ong, Carsten Bergmann, Oliver Wessely
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications Ltd 2026-02-01
Schriftenreihe:eLife
Schlagworte:
ADPKD
chronic kidney disease
genetic modifier
translational control
EO-ADPKD
VEO-ADPKD
Online-Zugang:https://elifesciences.org/articles/106342
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