Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Abstract Monkeypox virus (MPXV), an orthopoxvirus that has long been endemic in Africa, has posed a significant global health threat since 2022. The I7L protease, a highly conserved cysteine proteinase essential for orthopoxvirus replication, represents a promising target for broad‐spectrum antivira...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-07-01
coleção:	Advanced Science
Assuntos:	covalent inhibitors I7L protease monkeypox virus protein structures substrate proteolysis
Acesso em linha:	https://doi.org/10.1002/advs.202501625
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!