A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance

Abstract Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long‐lived IIS mutants has been extensively documented, the causal mechanisms contributing to extended lifespa...

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Bibliografske podrobnosti

Principais autores:	Luke S Tain, Robert Sehlke, Chirag Jain, Manopriya Chokkalingam, Nagarjuna Nagaraj, Paul Essers, Mark Rassner, Sebastian Grönke, Jenny Froelich, Christoph Dieterich, Matthias Mann, Nazif Alic, Andreas Beyer, Linda Partridge
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer Nature 2017-09-01
Serija:	Molecular Systems Biology
Teme:	ageing insulin/IGF mitochondria proteasome proteome
Online dostop:	https://doi.org/10.15252/msb.20177663
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