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The Preclinical Validation of 405 nm Light Parasiticidal Efficacy on <i>Leishmania donovani</i> in Ex Vivo Platelets in a Rag2<sup>−/−</sup> Mouse Model

Violet–blue light of 405 nm in the visible spectrum at a dose of 270 J/cm<sup>2</sup> alone has been shown to be an effective microbicidal tool for inactivating several bacteria, HIV-1, and <i>Trypanosoma cruzi</i> in ex vivo plasma and platelets. Unlike chemical- and ultraviolet (UV)-based pathogen...

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Principais autores: Pravin R. Kaldhone, Nazli Azodi, Hannah L. Markle, Neetu Dahiya, Caitlin Stewart, John Anderson, Scott MacGregor, Michelle Maclean, Hira L. Nakhasi, Sreenivas Gannavaram, Chintamani Atreya
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-01-01
Serier:Microorganisms
Fag:
405 nm light
platelets
<i>Leishmania</i>
pathogen reduction
transfusion transmissible parasites
transfusion safety
Online adgang:https://www.mdpi.com/2076-2607/12/2/280
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