The SWIB domain-containing DNA topoisomerase I of Chlamydia trachomatis mediates DNA relaxation

ABSTRACT Chlamydia trachomatis has a DNA topoisomerase I with a unique C-terminal domain (CTD) homologous to eukaryotic SWIB domains. This study focused on determining the function of the SWIB domain-containing TopA from C. trachomatis (CtTopA). We demonstrated that, despite the lack of sequence sim...

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Autori principali:	Li Shen, Abigail R. Swoboda, Caitlynn Diggs, Shomita Ferdous, Andrew Terrebonne, Amanda Santos, Noel Wolf, Luis Lorenzo Carvajal, Guangming Zhong, Scot P. Ouellette, Yuk-Ching Tse-Dinh
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2025-09-01
Serie:	Journal of Bacteriology
Soggetti:	Chlamydia trachomatis DNA topoisomerase I (TopA) DNA relaxation SWIB domain transcriptional regulation chlamydial developmental cycle
Accesso online:	https://journals.asm.org/doi/10.1128/jb.00190-25
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