The impact of the conjugation manner of targeting agent and tandem cell-penetrating peptide on the efficacy of mitomycin C liposomes in treating triple-negative breast tumors

Triple-negative breast cancer (TNBC) remains one of the most aggressive subtypes with limited therapeutic options. To address this unmet need, this study aimed to enhance the cellular uptake and cytotoxicity of mitomycin C (MMC) using surface-modified nanoliposomes functionalized with poly-L-arginin...

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Autors principals:	Mehrnaz Salahi, Jaleh Varshosaz, Mahboubeh Rostami, Salar Nasr Esfahani, Arsham Hekmat, Ali Jahanian-Najafaabadi, Mohsen Minayian
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-12-01
Col·lecció:	International Journal of Pharmaceutics: X
Matèries:	L-arginine Chondroitin sulfate Mitomycin C N-(3-dimethylaminopropyl)-N'-ethyl carbodiimide hydrochloride Propidium iodide Penicillin-streptomycin
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2590156725001422
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