Enhanced IL-1β Release Following NLRP3 and AIM2 Inflammasome Stimulation Is Linked to mtROS in Airway Macrophages in Pulmonary Fibrosis

Fibrotic Interstitial lung diseases (ILDs) are complex disorders of variable clinical behaviour. The majority of them cause significant morbidity, whilst Idiopathic Pulmonary Fibrosis (IPF) is recognised as the most relentless. NLRP3, AIM2, and NLRC4 inflammasomes are multiprotein complexes driving...

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Auteurs principaux:	Athina Trachalaki, Eliza Tsitoura, Semeli Mastrodimou, Rachele Invernizzi, Eirini Vasarmidi, Eleni Bibaki, Nikolaos Tzanakis, Philip L. Molyneaux, Toby M. Maher, Katerina Antoniou
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2021-06-01
Collection:	Frontiers in Immunology
Sujets:	IPF – idiopathic pulmonary fibrosis ILD NLRP3 AIM2 NLRC4 mtROS
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.661811/full
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