The association of TNF-alpha secretion and mtDNA copy number in CD14+ monocytes of patients with obesity and CHD

IntroductionMitochondrial dysfunction may be one of the causes of inflammatory activation of monocytes and macrophages, which leads to excessive secretion of inflammatory mediators and the development of chronic inflammation.AimsThe study was aimed to evaluate the secretion of inflammatory cytokine...

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Autores principales:	Taisiya V. Tolstik, Tatiana V. Kirichenko, Alexander M. Markin, Anastasia I. Bogatyreva, Yuliya V. Markina, Diana G. Kiseleva, Nataliya N. Shaposhnikova, Antonina V. Starodubova, Alexander N. Orekhov
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2024-03-01
Colección:	Frontiers in Molecular Biosciences
Materias:	CD14+ monocytes primary culture TNF-α mitochondrial DNA copy number obesity coronary heart disease
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fmolb.2024.1362955/full
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