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A novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells

Mesenchymalization is a cellular and molecular program in which epithelial cells progressively lose their well-differentiated phenotype and adopt mesenchymal characteristics. Tumor mesenchymalization occurs during the progression of cancer to metastatic disease, and is also associated with resistanc...

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Principais autores: Justin M. David, Charli Dominguez, Kristen K. McCampbell, James L. Gulley, Jeffrey Schlom, Claudia Palena
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2017-10-01
Serier:OncoImmunology
Fag:
emt
fusion protein
immunotherapy
nsclc
pd-l1
tgf-β1
Online adgang:http://dx.doi.org/10.1080/2162402X.2017.1349589
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