Population pharmacokinetics of voriconazole and initial dosage optimization in patients with talaromycosis

The high variability and unpredictability of the plasma concentration of voriconazole (VRC) pose a major challenge for clinical administration. The aim of this study was to develop a population pharmacokinetics (PPK) model of VRC and identify the factors influencing VRC PPK in patients with talaromy...

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Detalhes bibliográficos

Principais autores:	Zhiwen Jiang, Yinyi Wei, Weie Huang, Bingkun Li, Siru Zhou, Liuwei Liao, Tiantian Li, Tianwei Liang, Xiaoshu Yu, Xiuying Li, Changjing Zhou, Cunwei Cao, TaoTao Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-09-01
coleção:	Frontiers in Pharmacology
Assuntos:	voriconazole talaromycosis population pharmacokinetics dosage optimization Monte Carlo simulation C- reactive protein (CRP)
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2022.982981/full
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