Inhibition of mir-155-5p alleviates cardiomyocyte pyroptosis induced by hypoxia/reoxygenation via targeting SIRT1-mediated activation of the NLRP3 inflammasome

Abstract Objective The hypoxia/reoxygenation (H/R)-induced pyroptosis of cardiomyocytes plays a crucial role in the pathogenesis of myocardial infarction (MI). miR-155-5p represents a promising target for MI therapy. However, its involvement in H/R-induced pyroptosis remains unclear. Methods The H/R...

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Detalhes bibliográficos

Principais autores:	Qiuyu Lu, Qingrong Shen, Jinmei Su, Xin Li, Bingyu Xia, Aicun Tang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-02-01
Colecção:	Journal of Cardiothoracic Surgery
Assuntos:	Myocardial infarction Hypoxia/reoxygenation Cardiomyocyte Pyroptosis NLRP3 inflammasome
Acesso em linha:	https://doi.org/10.1186/s13019-025-03366-1
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