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HEPARANASE AND AUTOIMMUNE DIABETES

Heparanase (Hpse) is the only known mammalian endo-β-D-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs). Hpse plays a homeostatic role in regulating the turnover of cell-associated HS and also degrade...

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Glavni autori: Charmaine Joy Simeonovic, Andrew eZiolkowski, Zuopeng eWu, Fui Jiun eChoong, Craig eFreeman, Christopher eParish
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2013-12-01
Serija:Frontiers in Immunology
Teme:
Diabetes Mellitus, Type 1
Inflammation
Islets of Langerhans
Heparan sulfate
vascular complications of diabetes
Heparanase
Online pristup:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00471/full
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