The Nontypeable <named-content content-type="genus-species">Haemophilus influenzae</named-content> Major Adhesin Hia Is a Dual-Function Lectin That Binds to Human-Specific Respiratory Tract Sialic Acid Glycan Receptors

ABSTRACT NTHi is a human-adapted pathogen that colonizes the human respiratory tract. Strains of NTHi express multiple adhesins; however, there is a unique, mutually exclusive relationship between the major adhesins Hia and HMW1 and HMW2 (HMW1/2). Approximately 25% of NTHi strains express Hia, a pha...

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Hlavní autoři:	John M. Atack, Christopher J. Day, Jessica Poole, Kenneth L. Brockman, Jamie R. L. Timms, Linda E. Winter, Thomas Haselhorst, Lauren O. Bakaletz, Stephen J. Barenkamp, Michael P. Jennings
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2020-12-01
Edice:	mBio
Témata:	COPD NTHi adhesin autotransporter proteins bacterial pathogen glycan
On-line přístup:	https://journals.asm.org/doi/10.1128/mBio.02714-20
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