Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
Abstract The HSP90/CDC37 chaperone system not only assists the maturation of many protein kinases but also maintains their structural integrity after folding. The interaction of mature kinases with the HSP90/CDC37 complex is governed by the conformational stability of the catalytic domain, while the...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Portfolio
2022-02-01
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| Reeks: | Scientific Reports |
| Online toegang: | https://doi.org/10.1038/s41598-022-06423-0 |
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