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Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors

Abstract While the excessive inflammation in cancer cachexia is well-known to be induced by the overproduction of inflammatory mediators in the periphery, microflora disruption and brain dysfunction are also considered to contribute to the induction of cancer cachexia. Hypothalamic microglia play a...

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Главные авторы: Yukari Suda, Keiko Nakamura, Fukiko Matsuyama, Yusuke Hamada, Hitoshi Makabe, Michiko Narita, Yasuyuki Nagumo, Tomohisa Mori, Naoko Kuzumaki, Minoru Narita
Формат: Artigo
Язык:Inglês
Опубликовано: BMC 2024-04-01
Серии:Molecular Brain
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Online-ссылка:https://doi.org/10.1186/s13041-024-01091-9
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