Combining Mitomycin C with inhibition of BAD phosphorylation enhances apoptotic cell death in advanced cervical cancer

Objective: Mitomycin C (MMC), a DNA-damaging chemotherapeutic, is commonly used clinically for recurrent cervical carcinoma (CC), either alone or in combination. MMC generates DNA damage resulting in CC cell death yet also induces increased AKT-BAD phosphorylation associated with drug resistance and...

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Detalhes bibliográficos

Principais autores:	Liqiong Wang, Xi Zhang, Shu Chen, Qiuhua Ye, Basappa Basappa, Tao Zhu, Peter E. Lobie, Vijay Pandey
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-11-01
coleção:	Translational Oncology
Assuntos:	BAD phosphorylation Mitomycin C Apoptosis cervical cancer N-cyclopentyl-3-((4-(2,3-dichlorophenyl) piperazin-1-yl) (2-hydroxyphenyl) methyl) benzamide (NPB)
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1936523324002304
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