Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch

Methylation of proteins and nucleic acids plays a fundamental role in epigenetic regulation, and discovery of methyltransferase (MT) inhibitors is an area of intense activity. Because of the diversity of MTs and their products, assay methods that detect S-adenosylhomocysteine (SAH) – the invariant p...

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Detalhes bibliográficos

Principais autores:	Ha Pham, Meera Kumar, Anibal Ramos Martinez, Mahbbat Ali, Robert G. Lowery
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-06-01
coleção:	SLAS Discovery
Assuntos:	Epigenetics Histone methyltransferase DNA methyltransferase Methyltransferase assay Aptamer Riboswitch
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2472555224000236
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