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Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair

Abstract Recent studies report that epithelial differentiated cells can undergo a reverse process called dedifferentiation in response to stem cell loss. However, the extent of this reversion and the plasticity of young versus aged-differentiated cells remain unclear. Here we show that dedifferentia...

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Autors principals: Shalini Dimri-Wagh, Swarnabh Bhattacharya, Gharam Yassen, Ofir Shorer, Aya Amitai-Lange, Anna Altshuler, Shira Hadad-Porat, Keren Yizhak, Yuval Shaked, Michael Mimouni, Beatrice Tiosano, Ramez Barbara, Ruby Shalom-Feuerstein
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2026-04-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-026-72331-w
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