iRhom2 regulates HMGB1 secretion to modulate inflammation and hepatocyte senescence in an in vitro model of ischemia-reperfusion injury

Abstract Ischemia-reperfusion injury (IRI) represents a major challenge in liver transplantation, driving acute dysfunction and contributing to long-term allograft rejection. This process triggers a robust inflammatory response, leading to hepatocyte damage, senescence, and impaired liver regenerati...

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Auteurs principaux:	Matteo Calligaris, Riccardo Perriera, Claudia Carcione, Vitale Miceli, Margot Lo Pinto, Rosalia Busà, Giandomenico Amico, Matteo Bulati, Caterina Amato, Duilio Pagano, Pier Giulio Conaldi, Simone Dario Scilabra, Massimo Pinzani, Giovanni Zito
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 2026-01-01
Collection:	Cell Death and Disease
Accès en ligne:	https://doi.org/10.1038/s41419-025-08256-x
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