Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8+ T cell antitumor immunity

Abstract Background The role of Mediator complex subunit 1 (MED1), a pivotal transcriptional coactivator implicated in diverse biological pathways, remains unexplored in the context of oral squamous cell carcinoma (OSCC). This study aims to elucidate the contributory mechanisms and potential impact...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Zhe Li, Mengke Sun, Ruimeng Yang, Zheng Wang, Qianyu Zhu, Yue Zhang, Haosun Yang, Zhaosong Meng, Lizhi Hu, Lei Sui
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-09-01
Edice:	Journal of Experimental & Clinical Cancer Research
Témata:	The Mediator complex subunit 1 Matrix metalloprotein 9 Transcriptional regulation Programmed death-ligand 1 Notch signaling pathway Oral squamous cell carcinoma
On-line přístup:	https://doi.org/10.1186/s13046-024-03191-9
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!