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Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive

Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. For its clinical course, host genetic factors are important and rare genomic variants are suspected to contribute. We sequenced the exomes of 59 Greek and 15 German patients with bacterial sepsis divide...

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Autors principals: Stefan Taudien, Ludwig Lausser, Evangelos J. Giamarellos-Bourboulis, Christoph Sponholz, Franziska Schöneweck, Marius Felder, Lyn-Rouven Schirra, Florian Schmid, Charalambos Gogos, Susann Groth, Britt-Sabina Petersen, Andre Franke, Wolfgang Lieb, Klaus Huse, Peter F. Zipfel, Oliver Kurzai, Barbara Moepps, Peter Gierschik, Michael Bauer, André Scherag, Hans A. Kestler, Matthias Platzer
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016-10-01
Col·lecció:EBioMedicine
Matèries:
Sepsis
Exome
Rare single nucleotide variation
Population stratification
Classification
Semantic set covering machine
Accés en línia:http://www.sciencedirect.com/science/article/pii/S2352396416303930
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