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Interpreting immune evasion: a novel assay for HLA loss detection

This study presents the analytical performance of a new Next-Generation Sequencing (NGS) assay designed to detect Human Leukocyte Antigen (HLA) loss. Unlike existing methods, this assay offers increased sensitivity, broader applicability, and does not require prior knowledge of specific HLA mismatch...

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Gardado en:
Principais autores: Linnéa Pettersson, Sofia Westerling, Hamid Ramezanali, Francesco Vezzi, Rikard Eckerud, Dan Hauzenberger, Anders Hedrum, Jonas Mattsson, Michael Uhlin, Mehmet Uzunel
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Assuntos:
HSCT
NGS
HLA loss
immune evasion
haplo identical hematopoietic stem cell transplantation
MMUD-HSCT
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603188/full
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