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Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?

GPVI is a critical signaling receptor responsible for collagen-induced platelet activation and a promising anti-thrombotic target in conditions such as coronary artery thrombosis, ischemic stroke, and atherothrombosis. This is due to the ability to block GPVI while having minimal effects on hemostas...

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Main Authors: Joanne C. Clark, Foteini-Nafsika Damaskinaki, Yam Fung Hilaire Cheung, Alexandre Slater, Steve P. Watson
Format: Artigo
Language:Inglês
Published: Taylor & Francis Group 2021-08-01
Series:Platelets
Subjects:
gpvi
dimerization
platelets
ligands
structure-function
Online Access:http://dx.doi.org/10.1080/09537104.2021.1887469
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