Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness

Abstract Background Mitochondrial DNA (mtDNA) is present at high copy numbers in animal cells, and though characterized by a single haplotype in each individual due to maternal germline inheritance, deleterious mutations and intact mtDNA molecules frequently co-exist (heteroplasmy). A number of fact...

詳細記述

書誌詳細

主要な著者:	Lana Meshnik, Dan Bar-Yaacov, Dana Kasztan, Tali Neiger, Tal Cohen, Mor Kishner, Itay Valenci, Sara Dadon, Christopher J. Klein, Jeffery M. Vance, Yoram Nevo, Stephan Züchner, Ofer Ovadia, Dan Mishmar, Anat Ben-Zvi
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2022-02-01
シリーズ:	BMC Biology
主題:	C. elegans fzo-1 Heteroplasmy inheritance Mitofusin mtDNA PARKIN
オンライン･アクセス:	https://doi.org/10.1186/s12915-022-01241-2
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!