Fatty Acids Abolish Shigella Virulence by Inhibiting Its Master Regulator, VirF

ABSTRACT The pathogenicity of Shigella, the intracellular pathogen responsible for human bacillary dysentery, depends on a coordinated and tightly regulated expression of its virulence determinants. This is the result of a cascade organization of its positive regulators, with VirF, a transcriptional...

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Bibliographic Details

Main Authors:	Rita Trirocco, Martina Pasqua, Angela Tramonti, Milena Grossi, Bianca Colonna, Alessandro Paiardini, Gianni Prosseda
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2023-06-01
Series:	Microbiology Spectrum
Subjects:	bacterial pathogens Shigella virulence AraC-XylS regulators fatty acids
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.00778-23
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