Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death

Abstract Background Oxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its selective RPE cell damage makes it as a reproducible model of AMD. Although NaIO3 is an oxidat...

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Principais autores:	Chi-Ming Chan, Duen-Yi Huang, Ponarulselvam Sekar, Shu-Hao Hsu, Wan-Wan Lin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-05-01
coleção:	Journal of Biomedical Science
Assuntos:	Retinal epithelium Reactive oxygen species Sodium iodate Mitochondrial dynamics Autophagy Age-related macular degeneration
Acesso em linha:	http://link.springer.com/article/10.1186/s12929-019-0531-z
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