Impact of naturally occurring hemagglutinin substitutions on antigenicity and fitness of influenza A(H5N1) virus

Abstract In 2024, a human infection with clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) virus was identified in the United States in an individual with no known exposure. Genetic analysis revealed two hemagglutinin (HA) substitutions, P136S and A156T, which may alter viral antigenicity. Vi...

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Autori principali:	Li Wang, Masato Hatta, Chenchen Feng, Paul Carney, Melvyn R. Almanzar-Jordan, Jieru Wang, Jaber Hossain, Ginger Atteberry, Nacyra Assad-Garcia, Sydney Sheffield, Juliana DaSilva, Juan A. De La Cruz, Yasuko Hatta, Monique C. Johnson, Julia Frederick, Rebecca Hart, Kristine A. Lacek, Malania Wilson, Lisa M. Keong, Xudong Lin, Ying Huang, Michael Currier, Gene Tan, Sanjay Vashee, Vivien G. Dugan, Benjamin Rambo-Martin, Han Di, Marie K. Kirby, C. Todd Davis, James Stevens, Bin Zhou
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-10-01
Serie:	npj Viruses
Accesso online:	https://doi.org/10.1038/s44298-025-00154-5
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