GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis
Abstract Globally, approximately 1.3 million total joint implants are placed annually, and around 80,000 patients develop aseptic loosening, a leading cause of implant failure driven by peri-implant fibrosis. Here, we show that the BMP-antagonist Gremlin-1 (GREM1), expressed by leptin receptor–expre...
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| Główni autorzy: | , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Portfolio
2026-03-01
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| Seria: | Nature Communications |
| Dostęp online: | https://doi.org/10.1038/s41467-026-70111-0 |
| Etykiety: |
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