Design, Synthesis and Assay of Novel Methylxanthine–Alkynylmethylamine Derivatives as Acetylcholinesterase Inhibitors

Xanthine derivatives have been a great area of interest for the development of potent bioactive agents. Thirty-eight methylxanthine derivatives as acetylcholinesterase inhibitors (AChE) were designed and synthesized. Suzuki–Miyaura cross-coupling reactions of 8-chlorocaffeine with aryl(hetaryl)boron...

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Principais autores:	Danila V. Reshetnikov, Igor D. Ivanov, Dmitry S. Baev, Tatyana V. Rybalova, Evgenii S. Mozhaitsev, Sergey S. Patrushev, Valentin A. Vavilin, Tatyana G. Tolstikova, Elvira E. Shults
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-12-01
coleção:	Molecules
Assuntos:	methylxanthines caffeine theophylline theobromine A<sup>3</sup>-coupling reactions acetylcholinesterase inhibitor
Acesso em linha:	https://www.mdpi.com/1420-3049/27/24/8787
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