Implementation of nanographene oxide combined with mineral trioxide aggregate and hydroxyapatite biopolymer in regeneration of critical-sized bone defect in rats

Abstract Critical-sized bone defects (CSBDs) are causing a significant challenge in orthopedic surgery for their inability to heal spontaneously, demanding innovative biomaterials to enhance bone formation. Current therapies, as autografts and allografts, are restricted by donor site morbidity and i...

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Principais autores:	Amr H. Abdallah, Nesrine Ebrahim, Samar Saeed, Ahmed N. Abdallah, Samar H. Elsharkawy, Ahmed I. Abdelgalil, Wahid S. El Ghoul, Yasser M. A. Mohamed, Ashraf A. Shamaa
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-09-01
Series:	Scientific Reports
Assuntos:	Critical-sized bone defects Bioactive composite Nano-graphene Hydroxyapatite Mineral trioxide aggregate
Acceso en liña:	https://doi.org/10.1038/s41598-025-17233-5
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