Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

Background: Doxorubicin, an anthracycline chemotherapeutic agent, is widely used in the treatment of many cancers. However, doxorubicin posts a great risk of adverse cardiovascular events, which are thought to be caused by oxidative stress. We recently reported that the ubiquitin E3 ligase TRIM21 in...

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Detalhes bibliográficos

Principais autores:	Kai Hou, Jianliang Shen, Junrong Yan, Chuannan Zhai, Jingxia Zhang, Ji-An Pan, Ye Zhang, Yaping Jiang, Yongbo Wang, Richard Z. Lin, Hongliang Cong, Shenglan Gao, Wei-Xing Zong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-07-01
coleção:	EBioMedicine
Assuntos:	TRIM21 Antioxidant Doxorubicin Cardiotoxicity Ferroptosis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352396421002498
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