Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza.

Pandemic influenza A virus (IAV) remains a significant threat to global health. Preparedness relies primarily upon a single class of neuraminidase (NA) targeted antivirals, against which resistance is steadily growing. The M2 proton channel is an alternative clinically proven antiviral target, yet a...

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Autores principales:	Claire Scott, Jayakanth Kankanala, Toshana L Foster, Daniel H Goldhill, Peng Bao, Katie Simmons, Marieke Pingen, Matthew Bentham, Elizabeth Atkins, Eleni Loundras, Ruth Elderfield, Jolyon K Claridge, Joseph Thompson, Peter R Stilwell, Ranjitha Tathineni, Clive S McKimmie, Paul Targett-Adams, Jason R Schnell, Graham P Cook, Stephen Evans, Wendy S Barclay, Richard Foster, Stephen Griffin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2020-08-01
Colección:	PLoS Pathogens
Acceso en línea:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008716&type=printable
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